There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Matthew Scott |
| Institution: | Harvard Medical School/Massachusetts General Hospital |
| Department: | Neurology |
| Country: | |
| Proposed Analysis: | Sex-specific effects on clinical progression to Alzheimer’s disease (AD) suggest a greater risk in women in epidemiological studies, and evidence is building that sex differences may also exist in AD biomarkers such as β-amyloid (Aβ) and tau. Previous evidence points to greater tau burden in females relative to males, and our recent findings suggest that in individuals with high levels of Aβ, greater tau in the entorhinal and inferior temporal lobes exists in women more so than men. Up until this point, however, we had not examined tau burden across all regions of the brain. As such, our objective is to examine biological sex differences in tau deposition across the brain, measured via positron emission tomography (PET). Our question focused on whether females showed greater tau burden across extensive regions of the brain, or whether the effects were localized purely to AD-vulnerable regions of the brain. |
| Additional Investigators | |
| Investigator's Name: | Natalie Edwards |
| Proposed Analysis: | Previous work from Dr. Rachel Buckley using data from both the Harvard Aging Brain Study and ADNI have demonstrated that clinically normal females exhibit greater extra-temporal and temporal FTP-PET signal than males. We hope to further explore these findings using longitudinal FTP-PET data, examining rates of accumulation in FTP-PET across the brain in females versus males. We will be downloading FTP-PET data and closest MRI images. Lastly, this work is under the supervision of Dr. Rachel Buckley and in collaboration with Natalie Edwards (recently requested access). Natalie will be helping me gather image files on the ADNI site into a single collection to be downloaded. |
| Investigator's Name: | Rachel Buckley |
| Proposed Analysis: | Previous work from Dr. Rachel Buckley using data from both the Harvard Aging Brain Study and ADNI have demonstrated that clinically normal females exhibit greater extra-temporal and temporal FTP-PET signal than males. We hope to further explore these findings using longitudinal FTP-PET data, examining rates of accumulation in FTP-PET across the brain in females versus males. We will be downloading FTP-PET data and closest MRI images. Lastly, this work is under the supervision of Dr. Rachel Buckley and in collaboration with Natalie Edwards (recently requested access). |
