There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Valerie Treyer |
| Institution: | University of Zurich |
| Department: | Institute of Regenerative Medicine |
| Country: | |
| Proposed Analysis: | Age and Apo lipoprotein E (ApoE) genotype are established predictors for beta-amyloid load if measured across subjects, but the contribution to longitudinal amyloid accumulation when high beta-amyloid levels are already reached have been debated. We analyzed the contribution of these factors to amyloid accumulation over time in our longitudinal amyloid PET cohort study. Based on our dataset we postulate a model of this ApoE effect on amyloid accumulation that we would like to test in an independent data sample, where more amyloid-deposition is longitudinally assessed over at least three time points. The participants should have performed 3 or more Amyloid PET scans. For this analysis, we would need ApoE status, Amyloid and 3D T1 anatomical scans, age, gender and cognitive status information from ADNI/AIBL participants that were considered healthy controls or mildly cognitive impaired subjects at baseline. |
| Additional Investigators | |
| Investigator's Name: | Maha Wybitul |
| Proposed Analysis: | Investigation of the spatio-temporal pattern of amyloid accumulation in pre-dementia stages and the main influencing factors ApoE, tau pathology, and glucose metabolism. |
