There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Marlene Tahedl |
| Institution: | University of Regensburg |
| Department: | Chair of Psychiatry and Psychotherapy |
| Country: | |
| Proposed Analysis: | Cortical thickness is a measure that describes the width of the gray matter of the human cortex. It can be calculated from T1-weighted MR-images. In group studies, it has been shown to correlate with the diagnosis/prognosis of a number of neurologic and psychiatric conditions, including Alzheimer’s Disease (e.g. Shaw et al., 2016, Brain Topography). Recent work suggests that pathological brain aging can be differentiated from physiological aging by the progression of cortical thinning in the precuneus and inferior temporal regions (Lee et al., 2019, Frontiers in Aging Neuroscience). However, up until today, this measure has not been widely used in the clinical practice. One of the reasons for this might be that there is no reference system with which individual cortical thickness measures can be rated. Therefore, this study aims to (1) create representative reference standards for distinct age- and sex groups and (2) validate them on diagnosed patients with Alzheimer’s Disease. Such a standardized and validated system will help to monitor individual disease progression in AD. |
| Additional Investigators |
