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Principal Investigator  
Principal Investigator's Name: Gidon Levakov
Institution: Ben Gurion University of the Negev
Department: Brain and Cognitive Sciences
Country:
Proposed Analysis: Developing a Deep Learning framework for the prediction of chronological age from structural MRI scans. Previous findings associate an overestimation of brain age with neurodegenerative diseases and higher mortality rates. However, the importance of brain age prediction goes beyond serving as biomarkers for neurological disorders. Specifically, utilizing convolutional neural network (CNN) analysis to identify brain regions contributing to the prediction can shed light on the complex multivariate process of brain aging. Thus, my aim is to develop interpretable deep learning models to study normal aging and aging in the presence of neurodegenerative diseases
Additional Investigators  
Investigator's Name: Galia Avidan
Proposed Analysis: The overarching goal of the present proposal is to characterize structural brain changes in healthy individuals in a wide age range. This will be done by utilizing a machine learning model, with an automated minimal preprocessing pipeline for predicting age from structural brain images using a large dataset, thus allowing to estimate the gap between subjects biological and predicted age. We want to further examine how this gap is related to other health-related risk or resilience factors such as body mass. Moreover, we aim to provide interpretable results using a novel approach which we have adopted for the current settings.
Investigator's Name: Tammy Riklin Raviv
Proposed Analysis: The overarching goal of the present proposal is to characterize structural brain changes in healthy individuals in a wide age range. This will be done by utilizing a machine learning model, with an automated minimal preprocessing pipeline for predicting age from structural brain images using a large dataset, thus allowing to estimate the gap between subjects biological and predicted age. We want to further examine how this gap is related to other health-related risk or resilience factors such as body mass. Moreover, we aim to provide interpretable results using a novel approach which we have adopted for the current settings.
Investigator's Name: Ilan Shelef
Proposed Analysis: The overarching goal of the present proposal is to characterize structural brain changes in healthy individuals in a wide age range. This will be done by utilizing a machine learning model, with an automated minimal preprocessing pipeline for predicting age from structural brain images using a large dataset, thus allowing to estimate the gap between subjects biological and predicted age. We want to further examine how this gap is related to other health-related risk or resilience factors such as body mass. Moreover, we aim to provide interpretable results using a novel approach which we have adopted for the current settings.