There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Xiaoyan Zhang |
| Institution: | The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical |
| Department: | Department of Child Healthcare |
| Country: | |
| Proposed Analysis: | Emerging evidence has suggested that apolipoprotein C-III (APOC-III) is involved in the pathogenesis of Alzheimer’s disease (AD). To our knowledge, no studies have attempted to examine the longitudinal associations of APOC-III levels in plasma with changes in CSF AD pathologies (including Aβ42, total tau (t-tau) and phosphorylated tau (p-tau)) in non-demented older individuals. In the cross-sectional analysis, baseline plasma APOC-III levels were analyzed in relation to baseline CSF Aβ42, t-tau and p-tau levels in non-demented older adults (individuals with normal cognition (NC) and mild cognitive impairment (MCI)). Further, the longitudinal analysis was conducted with baseline plasma APOC-III used as predictor for changes in CSF Aβ42, t-tau and p-tau levels over a 7-year period. |
| Additional Investigators |
