There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Joleen Wong |
| Institution: | Singapore Institute of Technology |
| Department: | School of Health Sciences |
| Country: | |
| Proposed Analysis: | The principal objective of this research study is to identify if there is any relationship between white matter changes in the brain and cognitive function in an Asian population using Magnetic Resonance Imaging (MRI). This is achieved using various MRI sequences namely Diffusion Tensor Imaging (DTI) and Magnetisation-Prepared Rapid Gradient Echo (MPRAGE) alongside with the Addenbrooke’s Cognitive Exam III (Singapore-Version) (ACE-III-SG). MRI is chosen over other imaging modalities because it does not utilize ionizing radiation, and provides excellent contrast and anatomical differentiation between white matter, grey matter and cerebrospinal fluid. The hypothesis of the study is that cognitive function is associated with Brain Volumetry and the degree of changes of white matter tracts assessed by DTI. If so, these MRI findings could potentially serve as a preliminary biomarker for cognitive decline, enabling early identification and intervention to be provided to future patients at this imaging centre. |
| Additional Investigators | |
| Investigator's Name: | Wang Shen Lee |
| Proposed Analysis: | The principal objective of this research study is to identify if there is any relationship between white matter changes in the brain and cognitive function in an Asian population using Magnetic Resonance Imaging (MRI). This is achieved using various MRI sequences namely Diffusion Tensor Imaging (DTI) and Magnetisation-Prepared Rapid Gradient Echo (MPRAGE) alongside with the Addenbrooke’s Cognitive Exam III (Singapore-Version) (ACE-III-SG). MRI is chosen over other imaging modalities because it does not utilize ionizing radiation, and provides excellent contrast and anatomical differentiation between white matter, grey matter and cerebrospinal fluid. The hypothesis of the study is that cognitive function is associated with Brain Volumetry and the degree of changes of white matter tracts assessed by DTI. If so, these MRI findings could potentially serve as a preliminary biomarker for cognitive decline, enabling early identification and intervention to be provided to future patients at this imaging centre. |
| Investigator's Name: | Julian Gan |
| Proposed Analysis: | The principal objective of this research study is to identify if there is any relationship between white matter changes in the brain and cognitive function in an Asian population using Magnetic Resonance Imaging (MRI). This is achieved using various MRI sequences namely Diffusion Tensor Imaging (DTI) and Magnetisation-Prepared Rapid Gradient Echo (MPRAGE) alongside with the Addenbrooke’s Cognitive Exam III (Singapore-Version) (ACE-III-SG). MRI is chosen over other imaging modalities because it does not utilize ionizing radiation, and provides excellent contrast and anatomical differentiation between white matter, grey matter and cerebrospinal fluid. The hypothesis of the study is that cognitive function is associated with Brain Volumetry and the degree of changes of white matter tracts assessed by DTI. If so, these MRI findings could potentially serve as a preliminary biomarker for cognitive decline, enabling early identification and intervention to be provided to future patients at this imaging centre. |
