There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Mobina Keymasi |
| Institution: | Sepahan Institute of Higher Education Science & Technology |
| Department: | Faculty of Engineering |
| Country: | |
| Proposed Analysis: | In this study, a five-step algorithm is proposed to determine the functional connectivity of the brain in Alzheimer's disease using nonlinear correlation indexes in fMRI images. In the first step, a series of f MRI images for Alzheimer's resting mode is collected from the ADNI image database. Images in this database are stored in dicom format and taken in many time frames. Each batch of data relates to magnetic resonance imaging for several years from the brain of people with Alzheimer's. In the second step of this study, from several stages of filtration, normalization and smoothing, the images are being prepared for processing. In order to eliminate the effects of noise, it is used to remove the cut of the initial time of the image. In this step, images are converted to NIFTI format. In the third step, image processing is done. For this purpose, the Dozenbach Atlas has been used to extract 160 region of interest. These regions are used to examine brain connections. In the fourth step, on 160 region of interest, a set of nonlinear indicators for verifying brain connections between the areas of one year to another, is performed from one person's data. The goal is to indicate a significant reduction or significant increase in brain connections over time in the brain of patients with Alzheimer's disease. This is repeated for other patients. This comparison was also performed for Alzheimer's and healthy people. In this step, nonlinear indices of brain correlations (such as Granger causality nonlinear correlation index) have been used and statistical tests have been performed on it. In the fifth step, areas of the brain that have been shown to have a significant difference in brain communication with the help of the coordinates of the atlas, and the reduction or enhancement of brain communication from a physiological point of view. The results of this study showed that the connections of the memory sector after the passage of time Alzheimer's patients have a significant reduction. |
| Additional Investigators |
