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Principal Investigator  
Principal Investigator's Name: Li Liang
Institution: Harbin Institute of Technology at ShenZhen
Department: School of Electronic and Information Engineering
Country:
Proposed Analysis: 1. Use multi-modality neuroimaging techniques such as DWI, ASL, T1 and T2-FLAIR to explore the relationship between WMH burden and integrity of specific white matter tracts, and characterize the location of WMH within white matter network. 2. Lesion symptom mapping study: the relationship between cognitive impairments of specific domain and injury of strategic white matter tract. 3. Longitudinal investigation of white matter injury detected by neuroimaging associated with normal aging, MCI and AD.
Additional Investigators  
Investigator's Name: PengZheng Zhou
Proposed Analysis: Investigate the role of regional white matter lesions in AD related neurodegeneration through multi-modality neuroimaging study. How white matter lesions detected by T2-FLAIR and DWI associate with other AD-related imaging biomarkers, such as cortical atrophy.
Investigator's Name: PengZheng Zhou
Proposed Analysis: Investigate the role of regional white matter lesions in AD related neurodegeneration through multi-modality neuroimaging study. How white matter lesions detected by T2-FLAIR and DWI associate with other AD-related imaging biomarkers, such as cortical atrophy.