There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Danqing Xiao |
| Institution: | Regis College |
| Department: | STEM |
| Country: | |
| Proposed Analysis: | in vivo MRI imaging data will provide information on the integrity of pathways at a lower resolution (2nd). The goal of the analysis of these imaging study is to investigate whether there is any disconnection between the key brain structures among prefrontal cortex, hippocampus, thalamus and amygdala, as the microstructure of white matter changes and brain connectivity can be assessed by diffusion MRI data (Sanchez SM etal 2020). We will re-analyze the Diffusion Tension Imaging (DTI) datasets and the associated vascular ASL (arterial spin labeling) and diffusion-weighted MRI imaging data |
| Additional Investigators | |
| Investigator's Name: | Taylor Freeborn |
| Proposed Analysis: | to study the imaging data in elucidating the mechanism of AD in the connections point of view. A novel method called fixel-based analysis (Raffelt et al 2015) will be adopted for statistical analysis of white matter integrity in greater detail exhibiting within-voxel microstructures for complex fiber crossings in brain. FA, fractional anisotropy, and MD mean diffusivity, will be measured, a reflection of the strength of the connection. With the same approach, we will assess the vascular changes that are associated with the changes in long distance axonal connections. |
| Investigator's Name: | logan Bateman |
| Proposed Analysis: | to study the imaging data in elucidating the mechanism of AD in the connections point of view. A novel method called fixel-based analysis (Raffelt et al 2015) will be adopted for statistical analysis of white matter integrity in greater detail exhibiting within-voxel microstructures for complex fiber crossings in brain. FA, fractional anisotropy, and MD mean diffusivity, will be measured, a reflection of the strength of the connection. With the same approach, we will assess the vascular changes that are associated with the changes in long distance axonal connections. |
| Investigator's Name: | Luke theriault |
| Proposed Analysis: | DTI data |
