There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Tiantian Qiu |
| Institution: | Linyi People’s Hospital |
| Department: | Department of Radiology |
| Country: | |
| Proposed Analysis: | Subjective cognitive decline (SCD), characterized by subjective cognitive worsening in the absence of objective cognitive impairment, is very common among the elderly. Recent longitudinal studies have indicated that elderly patients with SCD have an increased risk of cognitive decline, as well as further progression to mild cognitive impairment (MCI) or Alzheimer’s disease (AD), suggesting that SCD could be the preclinical state of AD. Cerebral β-amyloid (Aβ) accumulation is recognized as a pathological hallmark of AD. Recent autopsy studies have verified that some elderly individuals with SCD have shown high levels of neuritic amyloid plaques. Importantly, SCD participants with high Aβ deposition in the brain were more likely to show symptoms of cognitive decline and even progression to dementia than SCD participants with low cerebral Aβ deposition. These findings suggested that different levels of cerebral Aβ accumulation in SCD participants could contribute to a distinct clinical prognosis. In addition to Aβ deposition, identifying cerebral functional and structural alterations underlying the Aβ burden in SCD may contribute to a better understanding of the pathophysiological mechanisms of SCD. The resting-state functional magnetic resonance imaging (rsfMRI) method, which could sensitively reflect early brain functional changes, has been applied to elderly individuals with SCD in recent years. Despite some studies having demonstrated cerebral functional and structural alterations of SCD, their relationship with Aβ deposition remains unknown. In the Alzheimer’s Disease Neuroimaging Initiative (ADNI), a comparable group of older adults were recruited with significant memory concerns (SMC) in the form of self-only complaints exceeding a predefined cut-off score on memory ratings. In this study, we aimed to investigate the possible different cerebral functional network and structural changes of participants with SMC with positive Aβ deposition (SMC+) and negative Aβ deposition (SMC-). |
| Additional Investigators |
