There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Claire Lancaster |
| Institution: | University of Sussex |
| Department: | Psychology |
| Country: | |
| Proposed Analysis: | We seek access to the ADNI dataset to address the following research questions: 1) How does ApoE genotype (e4 carrier vs. e3 homozygous; 0 vs. 1 vs. 2 e4 alleles) influence longitudinal change in resting-state functional connectivity in adults grouped by cognitive status (Healthy Aging, Significant Memory Concerns, Early – late Mild Cognitive Impairment). 2) Is there a correlation between ApoE differences in longitudinal resting-state functional connectivity and neuropsychological outcomes (cognition, everyday function, diagnosis)? 3) What is the impact of participant characteristics (sex, education, cardiovascular health) on the relationship between ApoE, resting-state functional connectivity and neuropsychological outcomes? 4) Is the relationship between ApoE and resting-state functional connectivity associated with the presence of Alzheimer’s pathology (amyloid, tau) or structural changes in regions of interest. The following data is requested for participants: 1) ApoE genotype, 2) Clinical outcomes (demographics, cognition, diagnostic summary), 3) Magnetic resonance imaging (fMRI connectivity, Structural MRI, Diffusion tensor imaging, arterial spin labelling, hippocampal T2, 4) PET imaging (tau, amyloid, FDG, PIB, Florbetapir), 5) CSF tau, amyloid-beta, plasma amyloid-beta 40 and 42. Cohort data will be included in linear-mixed effects models. |
| Additional Investigators |
