There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Sharon Lam |
| Institution: | Albert Einstein College of Medicine |
| Department: | Neurology |
| Country: | |
| Proposed Analysis: | In our study, we aim to examine the association between white matter hyperintensities (WMH) and cognitive domains such as memory and executive function (EF) in individuals who were cognitively normal (CN) or had mild cognitive impairment (MCI) across the spectrum of Alzheimer’s disease (AD) biomarker categories. Using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) at baseline, we will compile participants who are both CN and MCI. Based on the 2018 research framework, participants will be classified using AT(N) amyloid-β deposition [A], pathologic tau [T], and neurodegeneration [(N)]) biomarkers into one of 3 categories: biomarker negative (A-T-N-), amyloid negative but biomarker positive (A-T±N±) or amyloid positive (A+T±N±). Linear regressions will be used to test if WMH volume was associated with memory or EF in different diagnostic and biomarker subgroups. All statistical analyses will be conducted using SPSS, version 26.0 (Chicago, IL: SPSS Inc.). |
| Additional Investigators |
