There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Emily Rosenich |
| Institution: | Monash University |
| Department: | Turner Institute of Brain and Mental Health |
| Country: | |
| Proposed Analysis: | Vascular contributions to dementia are increasingly recognised. This suggests a need for the next generation of research to focus on how genetic (APOE ε4) and vascular risk factors interact to drive cerebrovascular disease, neurodegeneration, cognitive decline and progression to vascular and/or Alzheimer’s disease dementia. Our proposed analyses will investigate 1) the contribution of apolipoprotein E (APOE) ε4 and vascular risk factors on cognitive decline and progression to vascular and/or Alzheimer’s dementia in middle-aged and older adults, and 2) the contribution of APOE ε4 and vascular risk factors on cerebrovascular disease and neurodegeneration in middle-aged and older adults. To do this, we will leverage existing data and conduct a series of parallel analyses across multiple prospective cohort studies. Linear mixed effects models (LMMs) with random intercepts will be used to assess aims 1 and 2. Cohort-specific results will be pooled in a random-effects meta-analysis. |
| Additional Investigators | |
| Investigator's Name: | Yen Ying Lim |
| Proposed Analysis: | Vascular contributions to dementia are increasingly recognised. This suggests a need for the next generation of research to focus on how genetic (APOE ε4) and vascular risk factors interact to drive cerebrovascular disease, neurodegeneration, cognitive decline and progression to vascular and/or Alzheimer’s disease dementia. Our proposed analyses will investigate 1) the contribution of apolipoprotein E (APOE) ε4 and vascular risk factors on cognitive decline and progression to vascular and/or Alzheimer’s dementia in middle-aged and older adults, and 2) the contribution of APOE ε4 and vascular risk factors on cerebrovascular disease and neurodegeneration in middle-aged and older adults. To do this, we will leverage existing data and conduct a series of parallel analyses across multiple prospective cohort studies. Linear mixed effects models (LMMs) with random intercepts will be used to assess aims 1 and 2. Cohort-specific results will be pooled in a random-effects meta-analysis. |
| Investigator's Name: | Matthew Pase |
| Proposed Analysis: | Vascular contributions to dementia are increasingly recognised. This suggests a need for the next generation of research to focus on how genetic (APOE ε4) and vascular risk factors interact to drive cerebrovascular disease, neurodegeneration, cognitive decline and progression to vascular and/or Alzheimer’s disease dementia. Our proposed analyses will investigate 1) the contribution of apolipoprotein E (APOE) ε4 and vascular risk factors on cognitive decline and progression to vascular and/or Alzheimer’s dementia in middle-aged and older adults, and 2) the contribution of APOE ε4 and vascular risk factors on cerebrovascular disease and neurodegeneration in middle-aged and older adults. To do this, we will leverage existing data and conduct a series of parallel analyses across multiple prospective cohort studies. Linear mixed effects models (LMMs) with random intercepts will be used to assess aims 1 and 2. Cohort-specific results will be pooled in a random-effects meta-analysis. |
