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Principal Investigator  
Principal Investigator's Name: Rosie Walker
Institution: The University of Edinburgh
Department: School of Psychology
Country:
Proposed Analysis: Assessment of associations between APOE genoytpe and plasma, serum and CSF biomarkers (protein and metabolite levels) with aim of identifying candidate biomarkers to be investigated for putative causal role in AD using Mendelian randomisation methods.
Additional Investigators  
Investigator's Name: Charlotte Haynes
Proposed Analysis: Investigate the relationship between proteins levels (plasma and cerebrospinal fluid) and cognitive function. For proteins-of-interest, consider associations with brain structures and relevant variables such as measures of neuropathology and clinical variables.
Investigator's Name: Cecily Ward-Jackson
Proposed Analysis: Investigate the relationship between proteins levels (plasma and cerebrospinal fluid) and cognitive function. For proteins-of-interest, consider associations with brain structures and relevant variables such as measures of neuropathology and clinical variables.
Investigator's Name: Andrea Pujol-Busquets
Proposed Analysis: Investigate the relationship between proteins levels (plasma and cerebrospinal fluid) and cognitive function. For proteins-of-interest, consider associations with brain structures and relevant variables such as measures of neuropathology and clinical variables.
Investigator's Name: Samuel Bateman
Proposed Analysis: To investigate whether blood proteins are associated with key structural brain phenotypes, as measured by MRI, in a sex-dependent fashion, and to determine possible correlations/mediations of any significant associations found with lifestyle/environmental variables
Investigator's Name: Ting Yuan
Proposed Analysis: Investigating relationships between CSF protein levels and cognitive function as part of a taught MSc research project. For significant associations, mediation by structural brain phenotypes and clinical variables will be assessed.