There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | zili zhu |
| Institution: | wenzhou medical university |
| Department: | radiology |
| Country: | |
| Proposed Analysis: | In 2018, the National Institute on Aging-Alzheimer’s Association (NIA-AA) has proposed a biological definition of Alzheimer’s disease (AD): individuals with both abnormal amyloid and tau biomarkers (A+T+) would be defined as AD. It remains unclear why different cognitive status is present in subjects with biological AD. Resting-state functional magnetic resonance imaging(rsfmri) has provided an opportunity to reveal the brain activity patterns in a biologically-defined AD cohort. Accordingly, we want to investigate distinct brain activity patterns in subjects with existed AD pathology but in the different cognitive stages by selecting individuals with AD pathology (A+T+) and healthy controls (HC, A-T-) based on the cerebrospinal fluid (CSF) biomarkers. According to the cognitive stage, A+T+ cohort can be devided into three groups: (1) preclinical AD; (2) prodromal AD; and (3) AD with dementia (d-AD). We plan to compare spontaneous brain activity measured by an amplitude of low-frequency fluctuation (ALFF) approach among four groups. |
| Additional Investigators |
