There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Han Wu |
| Institution: | Fudan University |
| Department: | Nuclear Medicine Department of Huashan University |
| Country: | |
| Proposed Analysis: | Data will be used in the preparation of this study were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). The ADNI was launched in 2003 as a public-private partnership, led by Principal Investigator Michael W. Weiner, MD. The primary goal of ADNI has been to test whether serial magnetic resonance imaging (MRI), PET, other biological markers, and clinical and neuropsychological assessment can be combined to measure the progression of mild cognitive impairment (MCI) and early AD. Our study sample will be consisted of nondemented individuals who were cognitively normal (CN), presented subjective memory complaints (SMC), early mild cognitive impairment (EMCI) or late MCI (LMCI). Inclusion/exclusion criteria are described in detail at http://www.adni-info.org/. In brief, the included subjects will be between the ages of 55 and 90 years, completed at least 6 years of education, were fluent in Spanish or English, and were free of any significant neurological disease other than AD. These subjects will be recruited and assessed across different clinical sites in USA and Canada. Each site was assigned a principal investigator, a study physician, study coordinator, psychometrist, and a clinical dementia rating (CDR) scale rater. The principal investigator was responsible for overseeing all ADNI-related activities at their site. The study physician was responsible for conducting and supervising the clinical evaluation of all subjects, including physical and neurological examinations, reviewing adverse events and interpreting laboratory results. The psychometrist was in charge of the administration of the ADAS-Cog and the neuropsychological battery of tests, except the CDR scale, which was assessed by an independent rater, as mentioned above. All clinical sites were managed by the ADNI Clinical Core at the University of California (San Diego) and Mayo Clinic (Rochester). We will use MRI and Amyloid 18F-florbetapir PET images from ADNI to analyse. The preprocessed florbetapir data will be corregistered to the structural MRI scan, which was preprocessed using FreeSurfer (version 5.3; http://freesurfer.net/) as described elsewhere. The 18F-florbetapir means will be extracted from each cortical region included in the Desikan atlas in addition to the hippocampus and amydala. In addition, we will calculate a mean standardized uptake value ratio (SUVR) relative to a freesurfer-based reference region consisting of the whole cerebellum, the pons/brainstem region, and eroded cortical white matter. |
| Additional Investigators | |
| Investigator's Name: | Xingdang Liu |
| Proposed Analysis: | We will use MRI and Amyloid 18F-florbetapir PET images from ADNI to analyse. The preprocessed florbetapir data will be corregistered to the structural MRI scan, which was preprocessed using FreeSurfer (version 5.3; http://freesurfer.net/) as described elsewhere. The 18F-florbetapir means will be extracted from each cortical region included in the Desikan atlas in addition to the hippocampus and amydala. In addition, we will calculate a mean standardized uptake value ratio (SUVR) relative to a freesurfer-based reference region consisting of the whole cerebellum, the pons/brainstem region, and eroded cortical white matter. |
| Investigator's Name: | Yinghui Ou |
| Proposed Analysis: | We will use MRI and Amyloid 18F-florbetapir PET images from ADNI to analyse. The preprocessed florbetapir data will be corregistered to the structural MRI scan, which was preprocessed using FreeSurfer (version 5.3; http://freesurfer.net/) as described elsewhere. The 18F-florbetapir means will be extracted from each cortical region included in the Desikan atlas in addition to the hippocampus and amydala. In addition, we will calculate a mean standardized uptake value ratio (SUVR) relative to a freesurfer-based reference region consisting of the whole cerebellum, the pons/brainstem region, and eroded cortical white matter. |
| Investigator's Name: | Zhe Lei |
| Proposed Analysis: | We will use MRI and Amyloid 18F-florbetapir PET images from ADNI to analyse. The preprocessed florbetapir data will be corregistered to the structural MRI scan, which was preprocessed using FreeSurfer (v 5.3; http://freesurfer.net/) as described elsewhere. The 18F-florbetapir means will be extracted from each cortical region included in the Desikan atlas in addition to the hippocampus and amydala. In addition, we will calculate a mean standardized uptake value ratio (SUVR) relative to a freesurfer-based reference region consisting of the whole cerebellum, the pons/brainstem region, and eroded cortical white matter. |
