There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Dan Liu |
| Institution: | German Centre for Neurodegenerative Diseases (DZNE) |
| Department: | Population Health Sciences |
| Country: | |
| Proposed Analysis: | Decreased hippocampal volume has been associated with age-related memory decline as well as several neurodegenerative and neuropsychiatric disorders. However, the molecular determinants of hippocampal volume are still poorly understood. Epigenetic changes alter the expression of many neurotrophic genes and may mediate the effects of environment factors to age-related hippocampal atrophy. Therefore, we aimed to identify the epigenetic signatures associated with hippocampal volume through genome-wide DNA methylation profiling. |
| Additional Investigators |
