There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Thanh Vân Phan |
| Institution: | icometrix |
| Department: | Research and Development |
| Country: | |
| Proposed Analysis: | We are requesting access to use ADNI data for an independent and non-branded online educational program, ALZimaging. The aim is to educate (neuro)radiologists about the current and future paradigms of neuroimaging in the management of Alzheimer's disease in clinical practice. The educational program is sponsored by Biogen and is developed by icometrix in collaboration with Applied Radiology (AR) and the American Society of Neuroradiology (ASNR). A web-based Resource Center (alzimaging.com) will be implemented by icometrix, with accompanying supports, such as explanatory videos produced by AR and quarterly ACCME-accredited Spotlight Symposia organized by the ASNR. The Resource Center website consists of a balanced mixture of dynamic and static materials. The static part contains the scientific background information, presented as a “deep dive” page. It consists of an illustrated synthesis of the state-of-the-art in concise writing organized in key sections so that it is educative and pleasant to follow. The dynamic part includes a progression bar for motivating participants' engagement, 3D viewer of case studies for enhanced training, and quick quizzes for evaluating their acquired knowledge. This blended, interactive approach has been found to be most effective for training purposes and enables participants to consume content at their own pace. In order to provide extensive training, neuroimaging data are required to illustrate the different cases encountered in the management of AD, from early detection and differential diagnosis to patient monitoring on the disease progression and safety reading. Quizzes with case studies (with minimal information about the patient: age, gender, clinical symptoms or group) will enable us to measure how (neuro)radiologists perform in the diagnostic investigation of AD using neuroimaging. Therefore, ADNI data would be of great value in order to train (neuro)radiologists. ADNI data would be used: 1) As illustrative examples (figures) for supporting the written educational material 2) Anonymized data will be displayed in a 3D viewer so that (neuro)radiologists could scroll through the images in order to train for early diagnosis of AD, differential diagnosis (e.g., AD vs. Non-AD), and disease progression monitoring. 3) Neuroimaging data might be processed by icometrix for providing segmentation and volumetric measurements to (neuro)radiologists, in order to assess the utility of quantitative neuroimaging biomarkers. The website will comply with ISO13485, ISO27001, GDPR, and HIPAA to ensure data security and privacy. For example, the data can only be displayed in the 3D viewer, but cannot be downloaded by the participant! Although publications are not our primary goal, possible topics for publications could be about: - Neuroimaging protocol guidelines for the management of AD in clinical practice (review of methods) - Added-value of quantitative neuroimaging biomarkers in clinical practice (analysis of (neuro)radiologists performance). An acknowledgment will be of course added to the website, in case the ADNI committee accepts to share the data for this educational program. |
| Additional Investigators |
