There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Erin Harrell |
| Institution: | University of Alabama |
| Department: | Psychology |
| Country: | |
| Proposed Analysis: | Previous studies report hippocampal volume loss can help predict conversion from normative aging to mild cognitive impairment (MCI) to dementia. Additionally, a growing literature indicates that stress-related allostatic load may increase disease vulnerability. The current study will examine the relationship between stress related cytokines (i.e., interleukin-6 - IL-6), cognition as measured by Mini Mental Status scores (MMSE), and hippocampal volume. We propose using mixed-models to examine both within (across time) and between subjects effects of IL-6 and hippocampal volume on MMSE score among 566 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The following specification will be adopted for the analyses: Level 1: Y_it=β_0i+β_1 X_1it+β_2 X_2it+β_3 X_1it X_2it+ε_it Level 2: β_0i=β_01+β_02 Z_i+β_03 X ̅_1i+β_04 X ̅_2i+β_05 X ̅_1i X ̅_2i+u_0i β_1=β_10 β_2=β_20 β_3=β_30 where Y_it is the response of participant i at occasion t, X_1it and X_2it time-varying predictors, Z_i time-invariant covariates, X ̅_i individual-specific means of X_it. X_it will be centered at individual-specific means, and the individual-specific means will be included in the second level. |
| Additional Investigators | |
| Investigator's Name: | Chuong Bui |
| Proposed Analysis: | Previous studies report hippocampal volume loss can help predict conversion from normative aging to mild cognitive impairment (MCI) to dementia. Additionally, a growing literature indicates that stress-related allostatic load may increase disease vulnerability. The current study will examine the relationship between stress related cytokines (i.e., interleukin-6 - IL-6), cognition as measured by Mini Mental Status scores (MMSE), and hippocampal volume. We propose using mixed-models to examine both within (across time) and between subjects effects of IL-6 and hippocampal volume on MMSE score among 566 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The following specification will be adopted for the analyses: Level 1: Y_it=β_0i+β_1 X_1it+β_2 X_2it+β_3 X_1it X_2it+ε_it Level 2: β_0i=β_01+β_02 Z_i+β_03 X ̅_1i+β_04 X ̅_2i+β_05 X ̅_1i X ̅_2i+u_0i β_1=β_10 β_2=β_20 β_3=β_30 where Y_it is the response of participant i at occasion t, X_1it and X_2it time-varying predictors, Z_i time-invariant covariates, X ̅_i individual-specific means of X_it. X_it will be centered at individual-specific means, and the individual-specific means will be included in the second level. |
| Investigator's Name: | Sharlene Newman |
| Proposed Analysis: | Previous studies report hippocampal volume loss can help predict conversion from normative aging to mild cognitive impairment (MCI) to dementia. Additionally, a growing literature indicates that stress-related allostatic load may increase disease vulnerability. The current study will examine the relationship between stress related cytokines (i.e., interleukin-6 - IL-6), cognition as measured by Mini Mental Status scores (MMSE), and hippocampal volume. We propose using mixed-models to examine both within (across time) and between subjects effects of IL-6 and hippocampal volume on MMSE score among 566 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The following specification will be adopted for the analyses: Level 1: Y_it=β_0i+β_1 X_1it+β_2 X_2it+β_3 X_1it X_2it+ε_it Level 2: β_0i=β_01+β_02 Z_i+β_03 X ̅_1i+β_04 X ̅_2i+β_05 X ̅_1i X ̅_2i+u_0i β_1=β_10 β_2=β_20 β_3=β_30 where Y_it is the response of participant i at occasion t, X_1it and X_2it time-varying predictors, Z_i time-invariant covariates, X ̅_i individual-specific means of X_it. X_it will be centered at individual-specific means, and the individual-specific means will be included in the second level. |
