There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | HAIHONG LIU |
| Institution: | Chengde Medical University |
| Department: | Department of Psychology |
| Country: | |
| Proposed Analysis: | 1.Introduction Mild cognitive impairment (MCI) is an intermediate state between normal aging and early dementia, which is characterized by cognitive impairment and objective examination injury reported by the main complaint, and its daily life ability is basically normal[1] On the basis of whether cognitive impairment involves memory function, the MCI is divided into forgetting type (amnesia MCI,aMCI) and non-inheritance type (non-amnestic MCI,naMCI). According to the number of cognitive fields involved, it is further divided into single domain type and multi-domain type[2]. MCI, about 20% to 40%, develop dementia, a precursor to Alzheimer's disease. Initially, scholars agreed that MCI patients had situational memory defects, and later we found that MCI patients, including aMCI, also had executive function defects. There's only evidence that executive function potentially affects the coding of memory traces[3].Executive function is a cognitive function regulated by the prefrontal lobe, which refers to a series of cognitive processes required to set goals in daily life while controlling and coordinating the achievement of the goals[4],Three important dimensions including working memory, response inhibition and cognitive flexibility[5].The event-related potential (,ERP) technique has the advantage of high time resolution and can distinguish the sequence of cognitive processing stages well. ERP components are likely to be biological markers MCI early neurophysiological diagnosis[6].Therefore, it is possible to explore the damage characteristics and mechanisms of different subtypes MCI executive function from a ERP point of view to grasp the main link of MCI differential diagnosis.With regard to working memory, the researchers used ERP techniques to examine the working memory characteristics of MCI patients and young people in delayed sample matching (delayed matching-to-sample,DMS) tasks and found that there were defects in the process of memory extraction, which may be due to the central executive dysfunction of the central executive in charge of the middle return. The researchers examined the time-domain and frequency-domain characteristics of MCI patients in classical Go/NoGo tasks. The results showed that the P300 amplitude of MCI patients was lower than that of healthy elderly elderly under Go and NoGo conditions MCI, and the low frequency alpha energy of the top electrode position and the theta energy of the frontal region and the top region same conditions were significantly different[8].In terms of cognitive flexibility, behavioral studies have found that early cognitive deficits in vascular cognitive impairment are common[9],few ERP studies are currently relevant.To sum up,Most of the ERP studies on MCI executive function at home and abroad focus on working memory and response inhibition, but few studies explain the MCI of different subtypes,There are few studies on whether different subtypes MCI, such as aMCI and executive dysfunction dMCI, differ in their components[10].Therefore, this study intends to further explore the characteristics of executive function injury and cognitive neural mechanism of patients with different subtypes of MCI, and try to provide neurobiological markers for the differential diagnosis and evolution of MCI subtypes. 2.Research content, research objectives, key scientific issues to be addressed, innovations and expected results (1). research content Explore the characteristics and cognitive mechanism of executive function injury in patients with different subtypes MCI. Comparison of cross-sectional aMCI using psychometric, behavioral and EEG methods dMCI the cognitive response ability of patients and healthy elderly, and explore the damage characteristics of different subtypes MCI patients' working memory, reaction inhibition and cognitive flexibility. (2).research objectives (combination of quantitative and qualitative indicators) Through comparing the characteristics MCI executive function between patients with different subtypes and normal elderly and their EEG characteristics, the characteristics of executive function injury MCI different subtypes and their cognitive neural mechanism are clarified. 3.scientific issues to be addressed A key scientific issue to be addressed in this topic is the impairment characteristics of patients with different subtypes MCI in executive functions such as working memory, response inhibition and cognitive flexibility. We need to clarify whether MCI patients with different subtypes have injury and cognitive neural mechanism in the above executive function, and provide neurobiological markers for differential diagnosis MCI different subtypes. 4.Expected Outcomes From the behavioral, cognitive and neuroelectrophysiological aspects to clarify the different subtypes of MCI patients with functional injury characteristics and injury mechanisms. 5. Research Programmes and Feasibility Analysis (1).Research programme (description of relevant methods, technical routes, experimental means, key technologies, project feasibility analysis) Characteristics of executive function in patients with different subtypes of MCI: a clinical controlled study Objective: to compare the difference between executive function and normal elderly in aMCI and dMCI patients, and to explore the status of executive function injury and cognitive mechanism of injury in patients with different subtypes MCI. Subjects: in this study ,30 patients with aMCI and dMCI were selected as experimental groups, aged over 60 years old, with basic health, no physical disability, severe audio-visual disorders and major body diseases, excluding patients with severe head trauma, history of special drug use, patients with mental disorders, etc. At the same time ,30 healthy subjects were selected as the control group, and demographic aspects matched the experimental group. Experimental tasks :(1) neuropsychological test: basic information survey, simple mental state scale, Montreal cognitive assessment scale, clinical dementia rating scale, memory test (clinical memory scale, Wechsler digital breadth test, Wechsler story recall test), executive function test (stroop test, line test), speech test, daily life ability scale, flow center depression scale, etc. (2) ERP tasks: divided into resting state and task state, experimental tasks include digital n-back task, Go/no-go task and task transformation paradigm.. Experimental procedure:First of all, the subjects were screened by the main test with clinical experience of geriatric diseases. After the screening was passed, neuropsychological tests and ERP experiments were carried out. Data analysis: studies analyze behavioral and eeg data simultaneously, including digital n-back tasks, Go/no-go tasks, and task transformation paradigms. The study mainly investigated the resting brain functional network connection between the aMCI、dMCI group and the control group, and the differences in the amplitude of P2、N2 and P3 components. Reference [1] Petersen R C, Smith G E, Waring S C, et al. Mild cognitive impairment: Clinical characterization and outcome [J]. Archives of Neurology, 1999, 56(3): 303-308. [2] Petersen R C. Mild cognitive impairment as a diagnostic entity[J]. Journal of Internal Medicine, 2004, 256(3):183-194. [3] Diamond A. Executive functions [J]. Annual Review of Psychology, 2013, 64(1): 135-168. [4] Leist A K, Kulmala J, Nyqvist F. Health and Cognition in Old Age [M]. International Perspectives on Aging, 2014: 233-246. [5] 李美华, 白学军. 执行功能中认知灵活性发展的研究进展 [J]. 心理学探新, 2005, 25(02): 35-38+43. [6] Gu L, Zhang Z. Exploring Potential Electrophysiological Biomarkers in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Event-Related Potential Studies [J]. Journal of Alzheimers Disease, 2017, 58(4): 1283-1292. [7] Li B Y, Tang H D, Chen S D. Retrieval Deficiency in Brain Activity of Working Memory in Amnesic Mild Cognitive Impairment Patients: A Brain Event-Related Potentials Study [J]. Frontiers in Aging Neuroscience, 2016, 8(479):54. [8] Lopez Zunini R A, Knoefel F, Lord C, et al. P300 amplitude alterations during inhibitory control in persons with Mild Cognitive Impairment [J]. Brain Res, 2016, 1646(1):241-248. [9] Sudo F K, Amado P, Alves G S, et al. A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis [J]. Dementia & neuropsychologia, 2017, 11(4): 371-380. [10] Pa J, Boxer A, Chao L L, et al. Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment[J]. Annals of Neurology, 2010, 65(4):414-423. |
| Additional Investigators | |
| Investigator's Name: | XIAOLEI ZHANG |
| Proposed Analysis: | 1.Introduction Mild cognitive impairment (MCI) is an intermediate state between normal aging and early dementia, which is characterized by cognitive impairment and objective examination injury reported by the main complaint, and its daily life ability is basically normal[1] On the basis of whether cognitive impairment involves memory function, the MCI is divided into forgetting type (amnesia MCI,aMCI) and non-inheritance type (non-amnestic MCI,naMCI). According to the number of cognitive fields involved, it is further divided into single domain type and multi-domain type[2]. MCI, about 20% to 40%, develop dementia, a precursor to Alzheimer's disease. Initially, scholars agreed that MCI patients had situational memory defects, and later we found that MCI patients, including aMCI, also had executive function defects. There's only evidence that executive function potentially affects the coding of memory traces[3].Executive function is a cognitive function regulated by the prefrontal lobe, which refers to a series of cognitive processes required to set goals in daily life while controlling and coordinating the achievement of the goals[4],Three important dimensions including working memory, response inhibition and cognitive flexibility[5].The event-related potential (ERP) technique has the advantage of high time resolution and can distinguish the sequence of cognitive processing stages well. ERP components are likely to be biological markers MCI early neurophysiological diagnosis[6].Therefore, it is possible to explore the damage characteristics and mechanisms of different subtypes MCI executive function from a ERP point of view to grasp the main link of MCI differential diagnosis.With regard to working memory, the researchers used ERP techniques to examine the working memory characteristics of MCI patients and young people in delayed sample matching (delayed matching-to-sample,DMS) tasks and found that there were defects in the process of memory extraction, which may be due to the central executive dysfunction of the central executive in charge of the middle return. The researchers examined the time-domain and frequency-domain characteristics of MCI patients in classical Go/NoGo tasks. The results showed that the P300 amplitude of MCI patients was lower than that of healthy elderly elderly under Go and NoGo conditions MCI, and the low frequency alpha energy of the top electrode position and the theta energy of the frontal region and the top region same conditions were significantly different[8].In terms of cognitive flexibility, behavioral studies have found that early cognitive deficits in vascular cognitive impairment are common[9],few ERP studies are currently relevant.To sum up,Most of the ERP studies on MCI executive function at home and abroad focus on working memory and response inhibition, but few studies explain the MCI of different subtypes,There are few studies on whether different subtypes MCI, such as aMCI and executive dysfunction dMCI, differ in their components[10].Therefore, this study intends to further explore the characteristics of executive function injury and cognitive neural mechanism of patients with different subtypes of MCI, and try to provide neurobiological markers for the differential diagnosis and evolution of MCI subtypes. 2.Research content, research objectives, key scientific issues to be addressed, innovations and expected results (1). research content Explore the characteristics and cognitive mechanism of executive function injury in patients with different subtypes MCI. Comparison of cross-sectional aMCI using psychometric, behavioral and EEG methods dMCI the cognitive response ability of patients and healthy elderly, and explore the damage characteristics of different subtypes MCI patients' working memory, reaction inhibition and cognitive flexibility. (2).research objectives (combination of quantitative and qualitative indicators) Through comparing the characteristics MCI executive function between patients with different subtypes and normal elderly and their EEG characteristics, the characteristics of executive function injury MCI different subtypes and their cognitive neural mechanism are clarified. 3.scientific issues to be addressed A key scientific issue to be addressed in this topic is the impairment characteristics of patients with different subtypes MCI in executive functions such as working memory, response inhibition and cognitive flexibility. We need to clarify whether MCI patients with different subtypes have injury and cognitive neural mechanism in the above executive function, and provide neurobiological markers for differential diagnosis MCI different subtypes. 4.Expected Outcomes From the behavioral, cognitive and neuroelectrophysiological aspects to clarify the different subtypes of MCI patients with functional injury characteristics and injury mechanisms. 5. Research Programmes and Feasibility Analysis (1).Research programme (description of relevant methods, technical routes, experimental means, key technologies, project feasibility analysis) Characteristics of executive function in patients with different subtypes of MCI: a clinical controlled study Objective: to compare the difference between executive function and normal elderly in aMCI and dMCI patients, and to explore the status of executive function injury and cognitive mechanism of injury in patients with different subtypes MCI. Subjects: in this study ,30 patients with aMCI and dMCI were selected as experimental groups, aged over 60 years old, with basic health, no physical disability, severe audio-visual disorders and major body diseases, excluding patients with severe head trauma, history of special drug use, patients with mental disorders, etc. At the same time ,30 healthy subjects were selected as the control group, and demographic aspects matched the experimental group. Experimental tasks :(1) neuropsychological test: basic information survey, simple mental state scale, Montreal cognitive assessment scale, clinical dementia rating scale, memory test (clinical memory scale, Wechsler digital breadth test, Wechsler story recall test), executive function test (stroop test, line test), speech test, daily life ability scale, flow center depression scale, etc. (2) ERP tasks: divided into resting state and task state, experimental tasks include digital n-back task, Go/no-go task and task transformation paradigm.. Experimental procedure:First of all, the subjects were screened by the main test with clinical experience of geriatric diseases. After the screening was passed, neuropsychological tests and ERP experiments were carried out. Data analysis: studies analyze behavioral and eeg data simultaneously, including digital n-back tasks, Go/no-go tasks, and task transformation paradigms. The study mainly investigated the resting brain functional network connection between the aMCI、dMCI group and the control group, and the differences in the amplitude of P2、N2 and P3 components. Reference [1] Petersen R C, Smith G E, Waring S C, et al. Mild cognitive impairment: Clinical characterization and outcome [J]. Archives of Neurology, 1999, 56(3): 303-308. [2] Petersen R C. Mild cognitive impairment as a diagnostic entity[J]. Journal of Internal Medicine, 2004, 256(3):183-194. [3] Diamond A. Executive functions [J]. Annual Review of Psychology, 2013, 64(1): 135-168. [4] Leist A K, Kulmala J, Nyqvist F. Health and Cognition in Old Age [M]. International Perspectives on Aging, 2014: 233-246. [5] 李美华, 白学军. 执行功能中认知灵活性发展的研究进展 [J]. 心理学探新, 2005, 25(02): 35-38+43. [6] Gu L, Zhang Z. Exploring Potential Electrophysiological Biomarkers in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Event-Related Potential Studies [J]. Journal of Alzheimers Disease, 2017, 58(4): 1283-1292. [7] Li B Y, Tang H D, Chen S D. Retrieval Deficiency in Brain Activity of Working Memory in Amnesic Mild Cognitive Impairment Patients: A Brain Event-Related Potentials Study [J]. Frontiers in Aging Neuroscience, 2016, 8(479):54. [8] Lopez Zunini R A, Knoefel F, Lord C, et al. P300 amplitude alterations during inhibitory control in persons with Mild Cognitive Impairment [J]. Brain Res, 2016, 1646(1):241-248. [9] Sudo F K, Amado P, Alves G S, et al. A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis [J]. Dementia & neuropsychologia, 2017, 11(4): 371-380. [10] Pa J, Boxer A, Chao L L, et al. Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment[J]. Annals of Neurology, 2010, 65(4):414-423. |
