There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | mehrsa heidari |
| Institution: | Jondishapour University of Medical Sciences |
| Department: | medicine |
| Country: | |
| Proposed Analysis: | Alzheimer's is a type of dementia that affects memory, thinking and behavior. Symptoms eventually grow severe enough to interfere with daily tasks. Alzheimer's disease is believed to occur when abnormal amounts of amyloid beta, accumulating extracellularly as amyloid plaques, and tau proteins, accumulating intracellularly as neurofibrillary tangles, form in the brain affecting neuronal functioning and connectivity, resulting in a progressive loss of brain function. Progranulin is a highly conserved secreted protein that is expressed in multiple cell types, both in the CNS and in peripheral tissues. Both directly and via its conversion to granulins, progranulin regulates cell growth, survival, repair, and inflammation. Progranulin has a major role in regulation of lysosomal function and microglial responses in the CNS. Changes in progranulin (GRN) expression have been hypothesized to alter risk for Alzheimer’s disease (AD).According to Yonatan A. Cooper et al 2018 the relationship between GRN expression in peripheral blood and clinical diagnosis of AD and mild cognitive impairment (MCI). Temporal lobe structures are critical for memory function, white matter projections to the hippocampus may be compromised in individuals with mild Alzheimer's disease (AD), thereby compounding the memory difficulty. According to Wang et al 2012 demonstrated that white matter volume loss bilaterally in the PWM in patients with mild AD.We want to investigate the aforementioned issues in ADNI patients. We will use A voxel based morphometry approach for identifying the parahippocampal volume loss in Alzheimer patients. Progranulin detection will be based on biospecimen data, which is available in ADNI dataset.For statistical analysis our approach is SPSS program. |
| Additional Investigators |
