There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Katherine Duncan |
| Institution: | University of Toronto |
| Department: | Psychology |
| Country: | |
| Proposed Analysis: | We are interested in how different neurotransmitter systems relate to a person's cognitive trajectories while aging. As a proxy for the integrity of these neurotransmitter systems, we will specifically measure the volume of distinct basal forebrain regions, known to release acetylcholine to the medial temporal lobe and neocortex, respectively, along with the volume of the dopaminergic midbrain and the noradrenergic locus coeruleous. We will relate individual differences in the volume of these regions (corrected for whole brain volume) to a person's: (1) changes in performance on cognitive assessments of memory, executive function, and visual-spatial abilities across time; (2) changes in the dynamics of resting-state networks across time; (3) change in grey matter thickness in the neocortex across time; and (4) changes in hippocampal subregion volumes. We will additionally explore how these relationships may be moderated by sex, APOE genotypes, along with CSF tau and sAPP. With these analyses, we aim to identify both the overlapping influence of age-related declines in cholinergic, dopaminergic, and noradrenergic systems as well as how the decline in these systems uniquely initiates cascades of cognitive and neural outcomes. |
| Additional Investigators | |
| Investigator's Name: | Zahra Abolghasem |
| Proposed Analysis: | Will contribute to volumetric and cortical thickness analyses as well as analyses that integrate across measures. |
| Investigator's Name: | Buddhika Bellana |
| Proposed Analysis: | Will contribute to hippocampal subfield analyses as well as analyses that integrate across measures. |
| Investigator's Name: | Xiaoping Fang |
| Proposed Analysis: | Will contribute to dynamic resting state analyses as well as analyses that integrate across measures. |
| Investigator's Name: | Alexandra Decker |
| Proposed Analysis: | Will contribute to dynamic resting state analyses as well as analyses that integrate across measures. |
| Investigator's Name: | Ariana Youm |
| Proposed Analysis: | Will contribute to volumetric and cortical thickness analyses as well as analyses that integrate across measures. |
| Investigator's Name: | Thomas Biba |
| Proposed Analysis: | Will contribute to hippocampal subfield analyses as well as analyses that integrate across measures. |
