There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Greg Sutherland |
| Institution: | University of Sydney |
| Department: | Charles Perkins Centre |
| Country: | |
| Proposed Analysis: | We are a molecular neuropathology lab with a specific interest in the pathomechanisms of Alzheimer's disease (AD). We have previously explored the ROSMAP and UK Biobank data and reconfirmed the importance of APOE E4 as a major risk factor for AD. In particular UK Biobank has structural MRI but no PET data. We would therefore like to now take advantage of ADNI resources to further characterise the effects of APOE E4 on the brain and the relationships to region-specific amyloid and tau load (ADNI 3). Our hypothesis based on the ROSMAP pathological data is that APOE E4 is amyloid-related but not tau. More specifically that APOE E4 carriers will have more amyloid due to cerebral amyloid angiopathy in their occipital and parietal lobes. In contrast APOE E2 reduces amyloid load but only in the absence of APOE E4. |
| Additional Investigators | |
| Investigator's Name: | Andrew McCorkindale |
| Proposed Analysis: | Andrew is a PhD student in the Sutherland lab and will be responsible for the data analysis on the above mentioned proposal. Along with clinicopathological correlations in AD he has experience in MRI and DTI data analysis (PMID: 31765057) |
