There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Denise Head |
| Institution: | Washington University |
| Department: | Psychological & Brain Sciences |
| Country: | |
| Proposed Analysis: | ADNI Data Request Proposal Replication of an Inverse Association between the Hippocampus and Caudate Background. Research in the past has highlighted an inverse association between hippocampal and caudate volumes in both younger and older adults (Bohbot et al., 2007; Sodums & Bohbot, 2020). These observations indicate competitive age-related interactions between the two spatial navigation/memory systems supported by these structures. Previous studies analyzing such relationships were based on small sample sizes (ns = 30-51) and did not examine other brain regions. In addition, one recent study (Persson et al., 2018) suggested that there may be an initial increase in caudate volume followed by caudate atrophy during the progression of Alzheimer’s disease, but this was not directly examined. As a result, we would like to fill in the gaps in the literature and further solidify the interpretations of these findings. Data Requested. We would like to request access estimates of regional brain structure, cognitive performance, biomarker data (cerebrospinal fluid and PET) and CDR scores, including both cross-sectional and longitudinal data. The data would be used to address the following aims: Aim 1. Determine whether we can replicate the inverse association between hippocampal and caudate volume in a larger sample of clinically normal older adults. Aim 2. Determine whether the inverse association extends to other brain regions in the networks supporting the two navigation/memory systems. Aim 3. Examine the inverse association between hippocampal and caudate volumes across Alzheimer’s disease stages. Aim 4. Assess whether there are differential associations with cognitive tasks. Prior studies that focused on the inverse association observed associations of the caudate with stimulus-response strategies, and associations of the hippocampus with spatial strategies (Bohbot et al., 2007; Sodums & Bohbot, 2020). However, there is also evidence of both structures being associated with superior memory performance (Muller et al., 2018). |
| Additional Investigators |
