There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Rahul Patel |
| Institution: | University of Guelph |
| Department: | Psychology |
| Country: | |
| Proposed Analysis: | A similar analysis has been proposed previously under this account name (my name—Rahul), around summer 2019. My supervisor, Dr. Jordan Poppenk (jpoppenk@queensu.ca), has enlisted me as a co-investigator recently but I was not able to access the data. That's why I'm submitting the proposed analysis again to have access to the data once more as it will be necessary for publication purposes. ----- Alzheimer’s Disease (AD) patients have consistently shown declines in declarative memory, consolidation, and in many other cognitive areas. These changes are associated with atrophy and volumetric declines in medial temporal lobe structures, such as the hippocampus. Hippocampal atrophy has been associated with AD. Emerging research has quantified the position of the hippocampus via locating the uncal apex, a structure that divides the hippocampus into its anterior and posterior segments. Moreover, this research suggests that around the same time that symptoms develop in Alzheimer's Disease, the uncal apex undergoes a retraction toward the anterior extent of the hippocampus. However, the influence of Alzheimer's on the position of the uncal apex has not been longitudinally examined. The current study’s objective is to investigate changes in the position of the uncal apex of AD patients over the course of two years. The current study aims to draw upon the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data set, where I will segment a total of 438 hippocampi to subsequently determine uncal apex positions on the FreeSurfer software. From uncal apex y-positions transformed in MNI space, I will conduct a mixed model ANOVA to determine uncal apex positions among AD and control patients at 0 months (baseline) and after 24 months. These results may highlight a link between uncal apex movement and positioning with Alzheimer's early on. Finally, part of the neuroimaging examinations that are done on AD patients should examine uncal apex positions as a biomarker of early AD progression. |
| Additional Investigators | |
| Investigator's Name: | Jordan Poppenk |
| Proposed Analysis: | See previously proposed analysis |
| Investigator's Name: | Jordan Poppenk |
| Proposed Analysis: | See previously proposed analysis |
