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Principal Investigator  
Principal Investigator's Name: Masashi Honma
Institution: The University of Tokyo Hospital
Department: Department of Pharmacy
Country:
Proposed Analysis: In order to obtain the comprehensive and quantitative understanding of AD, including differences related to races, we are planning to analyze the US- and J-ADNI data statistically. We have already developed the statistical method "SReFT", with which we can estimate long-term chronological changes from fragmented observations in disease progression. Also, we analyzed the data from ADNI-1, GO, and 2 by applying SReFT. (Ishida, T. et.al., CPT, 2019, https://doi.org/10.1002/cpt.1166) Now, we are working on sophisticating the algorithm of SReFT and intend to integrate data from US- and J-ADNI for the analysis. While our access to the data from J-ADNI is already approved, we also need access to up-to-date US-ADNI data, including those from ADNI-3. This analysis would result in suggesting relevant biomarkers to describe the disease progression, which can develop further understanding of AD among Japanese and American patients.
Additional Investigators