There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Shamika Majmudar |
| Institution: | San Jose State University |
| Department: | Biological Sciences |
| Country: | |
| Proposed Analysis: | 1. Identify the role of the glutathione pathway in cognitive functions such as memory. 2. Identify the role or association of one or more of the TMEM14A, RPS16P5, MLIP-IT1, MIR5685, MCM3, LRRC1, GSTA7P, GSTA5, GSTA3, GSTA2, GFRAL, GCM1, FBXO9, FAM83B, ELOVL5, ABCA7, CLU, CR1, PICALM, PLD3, TREM2, and SORL1 genes in the hippocampus and dorsolateral prefrontal cortex with the glutathione pathway. 3. Identify possible mutations (SNPs) in genes that might have an epigenetic impact with respect to transcription start sites of the identified genes from the above original list of genes. 4. Carry out Chi-squared analysis of the identified SNPs from step 3 above between AD and control subjects to help determine if there is any relationship between such mutations can form the basis of an AD biomarker. |
| Additional Investigators |
