There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Min Jian |
| Institution: | Nanfang Hospital |
| Department: | Neurology |
| Country: | |
| Proposed Analysis: | Adiponectin (APN) is one of the adipokines primarily secreted exclusively from adipose tissue. Our previous animal experiment data showed that APN plays a protective role in Alzheimer’s disease. However, the level of APN on Alzheimer’s disease patients is unclear. The objective of this study was to examine the interactive effects of APN and AD on cognition and AD biomarkers. We would like to apply the Alzheimer's Disease Neuroimaging Initiative (ADNI) data to analyzed plasma APN concentrations; diagnostic status (i.e., MCI and dementia due to AD); Mini-Mental State Exam (MMSE) and Clinical Dementia Rating (CDR) Dementia Staging Instrument; cerebral spinal fluid (CSF) concentrations of amyloid-β peptide (Aβ42), total tau (t-Tau) and phosphorylated tau (p-Tau); fMRI and amyloid (AV45) PET imaging. Multivariable regression analyses tested the associations between plasma APN and risk genes including APOE on cognitive and biomarker outcomes. |
| Additional Investigators |
