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Principal Investigator  
Principal Investigator's Name: Heidi Jacobs
Institution: MGH / Harvard Medical School
Department: Radiology
Country:
Proposed Analysis: To examine the evolution of locus coeruleus metabolism as a function of AD pathologic change stages or diagnostic groups, and its relationship to pathology change; To identify and validate tracts connecting the locus coeruleus to the entorhinal cortex and examine tract integrity across the AD continuum.
Additional Investigators  
Investigator's Name: Elouise Koops
Proposed Analysis: To examine the evolution of LC metabolism as a function of AD pathologic change stages or diagnostic groups, and its relationship to pathology change; To identify tracts connecting the locus coeruleus to the entorhinal cortex.
Investigator's Name: Prokopis Prokopiou
Proposed Analysis: To examine the evolution of LC activity as a function of AD pathologic change stages or diagnostic groups, and its relationship to pathology change
Investigator's Name: Christoph Schneider
Proposed Analysis: To examine the evolution of LC activity as a function of AD pathologic change stages or diagnostic groups, and its relationship to pathology and cognitive change
Investigator's Name: Joost Riphagen
Proposed Analysis: To examine the evolution of LC activity as a function of pathology or diagnostic groups, and its relationship to genetics and cognitive change