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Principal Investigator  
Principal Investigator's Name: Naoya Oishi
Institution: Kyoto University Graduate School of Medicine
Department: Department of Psychiatry
Country:
Proposed Analysis: We are planning to extract effective features from MR or PET images in ADNI by pattern recognition methods based on mechine-learning techniques such as support vector machine (SVM). The extracted features will be applied not only to our own images in our facility but also to images by a multicenter study in Japan.
Additional Investigators  
Investigator's Name: Masanari Onda
Proposed Analysis: By examining changes in functional connectivity and linking them to each specific symptom, we can gain a better understanding of the underlying causes of the diverse range of symptoms in dementia. Through conducting translational research on each identified functional connectivity, we can contribute to the development of drugs tailored to target each specific symptom.
Investigator's Name: Toshiya Takahashi
Proposed Analysis: Patients with clinically diagnosed Alzheimer's disease have a varied clinical course and may or may not respond to cholinesterase inhibitors. We attempt to stratify Alzheimer's disease using neuropsychological testing, MRI, PET and spinal fluid testing, and to develop criteria for determining drug efficacy and prognosis, and to examine the association with genes.