There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Tianhua Yang |
| Institution: | west china hospital/sichuan university |
| Department: | Neurology |
| Country: | |
| Proposed Analysis: | “Initial ADNI Biospecimen Request: [ Tianhua Yang] – [APOE genotype influence on dynamic functional basal forebrain connectivity in Alzheimer’s disease]” The APOE genotype is the strongest genetic risk factor for Alzheimer’s disease (AD)1. The basal forebrain, the primary cholinergic source of neurons projecting to the cerebral cortex, was particularly affected by pathophysiologic alterations in patients with AD and in cognitively intact individuals2. However, the impact of APOE genotype influence on dynamic functional basal forebrain mechanisms remains to be identified. In our study, we sought to determine the impact of APOE genotype on dynamic basal forebrain connectivity in APOE4 and APOE4 mutation noncarriers with Alzheimer’s disease. Additionally, we aimed to address the influence of the APOE ε4 effects on basal forebrain dynamic connectivity in cognitively intact older adults at risk for AD and AD with APOE4 mutations from the perspective of dynamic point view. 1 Bussy, A. et al. Effect of Apolipoprotein E4 on Clinical, Neuroimaging, and Biomarker Measures in Noncarrier Participants in the Dominantly Inherited Alzheimer Network. Neurobiol Aging 75, 42-50 (2019). 2 Chiesa, P. A. et al. Relationship between Basal Forebrain Resting-State Functional Connectivity and Brain Amyloid-Beta Deposition in Cognitively Intact Older Adults with Subjective Memory Complaints. Radiology 290, 167-176 (2019). |
| Additional Investigators | |
| Investigator's Name: | Huanyu Zhou |
| Proposed Analysis: | “Initial ADNI Biospecimen Request: [ Tianhua Yang] – [APOE genotype influence on dynamic functional basal forebrain connectivity in Alzheimer’s disease]” The APOE genotype is the strongest genetic risk factor for Alzheimer’s disease (AD)1. The basal forebrain, the primary cholinergic source of neurons projecting to the cerebral cortex, was particularly affected by pathophysiologic alterations in patients with AD and in cognitively intact individuals2. However, the impact of APOE genotype influence on dynamic functional basal forebrain mechanisms remains to be identified. In our study, we sought to determine the impact of APOE genotype on dynamic basal forebrain connectivity in APOE4 and APOE4 mutation noncarriers with Alzheimer’s disease. Additionally, we aimed to address the influence of the APOE ε4 effects on basal forebrain dynamic connectivity in cognitively intact older adults at risk for AD and AD with APOE4 mutations from the perspective of dynamic point view. 1 Bussy, A. et al. Effect of Apolipoprotein E4 on Clinical, Neuroimaging, and Biomarker Measures in Noncarrier Participants in the Dominantly Inherited Alzheimer Network. Neurobiol Aging 75, 42-50 (2019). 2 Chiesa, P. A. et al. Relationship between Basal Forebrain Resting-State Functional Connectivity and Brain Amyloid-Beta Deposition in Cognitively Intact Older Adults with Subjective Memory Complaints. Radiology 290, 167-176 (2019). |
| Investigator's Name: | Huanyu Zhou |
| Proposed Analysis: | “Initial ADNI Biospecimen Request: [ Tianhua Yang] – [APOE genotype influence on dynamic functional basal forebrain connectivity in Alzheimer’s disease]” The APOE genotype is the strongest genetic risk factor for Alzheimer’s disease (AD)1. The basal forebrain, the primary cholinergic source of neurons projecting to the cerebral cortex, was particularly affected by pathophysiologic alterations in patients with AD and in cognitively intact individuals2. However, the impact of APOE genotype influence on dynamic functional basal forebrain mechanisms remains to be identified. In our study, we sought to determine the impact of APOE genotype on dynamic basal forebrain connectivity in APOE4 and APOE4 mutation noncarriers with Alzheimer’s disease. Additionally, we aimed to address the influence of the APOE ε4 effects on basal forebrain dynamic connectivity in cognitively intact older adults at risk for AD and AD with APOE4 mutations from the perspective of dynamic point view. 1 Bussy, A. et al. Effect of Apolipoprotein E4 on Clinical, Neuroimaging, and Biomarker Measures in Noncarrier Participants in the Dominantly Inherited Alzheimer Network. Neurobiol Aging 75, 42-50 (2019). 2 Chiesa, P. A. et al. Relationship between Basal Forebrain Resting-State Functional Connectivity and Brain Amyloid-Beta Deposition in Cognitively Intact Older Adults with Subjective Memory Complaints. Radiology 290, 167-176 (2019). |
