There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Lisa Lee |
| Institution: | Hoag Hospital |
| Department: | Neuropsychology |
| Country: | |
| Proposed Analysis: | The associated risk of Alzheimer’s disease linked to the APOE-e4 gene is similar in males and females (Wang, 2020). However, there is a disproportionate rate of Alzheimer’s in women (two-thirds) compared to men (Alzheimer’s Association, 2020). Mayeda et al. (2020) found that women who worked for pay during early adulthood and midlife, whether married or unmarried, had a slower rate of memory decline in later life compared to women who did not work for pay. Although there has been much research on the association between type of paid work or work environment and dementia; for instance, work complexity, job control, and job strain (Andel, 2012, Kroger, 2008, Seidler, 2004, Wang, 2012), there has been little research that includes unpaid work in ascertaining its effect on women and neurocognitive functioning later in life. This study aims to find whether paid work moderates the APOE-e4 gene in predicting the risk for Alzheimer’s disease (operationalized as Clinical Dementia Rating Scale total score at baseline) in women. |
| Additional Investigators |
