There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Morgan Levine |
| Institution: | Yale University |
| Department: | Pathology |
| Country: | |
| Proposed Analysis: | We have two projects for which we aim to use ADNI data. 1. The first involves the development of DNA methylation (DNAm) aging measures that can be assessed in blood, but reflect aging in brain and associated cognitive decline. For instance, we have a preliminary brain aging measure (based on blood DNAm) that shows validated associations with cognitive assessments in 2 independent cohorts. While the DNAm sample is smaller in ADNI, we propose to use it to further improve our measure. For instance, we will examine the association between various DNAm patterns and either predicted diagnosis, cognitive assessments, and/or neuroimaging data. We will then apply ensemble approaches to combine these results with our existing results (which are based on larger cohorts, but with less cognitive and/or AD-related phenotyping). Finally, we will utilize ADNI's repeat measure data to assess changes in DNAm as a function of changes in AD/dementia variables. Our lab has had great success developing aging biomarkers in blood and other tissues (including those in brain). However, these results will provide the first aging biomarker that is assessed in blood with the purpose of proxying aging in the brain. As such, it may have high relevance for pre-clinical screening and possibly secondary prevention. 2. We also have a project focused on resilience among individuals with APOE e4. We have recently conducted MD simulations and solution biophysics experiments to uncover novel interactions between APOE isoforms and lipid species. As such, we propose to use the ADNI lipidomics, genotyping, imaging, and cognitive data to determine whether interactions between lipids and APOE are associated with differential risk of AD dementia, and/or neuropathology. |
| Additional Investigators | |
| Investigator's Name: | Albert Higgins-Chen |
| Proposed Analysis: | Albert will be performing data analysis for the proposed studies. |
