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Principal Investigator  
Principal Investigator's Name: Huanyao Gao
Institution: Mayo Clinic
Department: Molecular Pharmacology & Experimental Therapeutics
Country:
Proposed Analysis: Mayo Clinic team Profs. Trushina and Wang are going to collaborate with Prof. Rima Kaddurah-Daouk and the Alzheimer’s Disease Metabolomics Consortium on this project aiming to identify potentially targetable pathways related to mitochondria metabolism and homeostasis in Alzheimer's disease. Specific aims include: 1. Identify appropriate transcriptomic, proteomic, metabolomic markers associated with bioenergetic deficiency/mitochondria dysfunction 2. Identify appropriate covariates for patient stratification, and 3. Discover drugs targeting these markers in different population
Additional Investigators  
Investigator's Name: Eugenia Trushina
Proposed Analysis: Mayo Clinic team Profs. Trushina and Wang are collaborating with Prof.Rima Kaddurah-Daouk and the Alzheimer’s Disease Metabolomics Consortium on this project aiming to identify potentially targetable pathways related to mitochondria metabolism and homeostasis in Alzheimer's disease. Specific aims include: 1. Identify appropriate transcriptomic, proteomic, metabolomic markers associated with bioenergetic deficiency/mitochondria dysfunction 2. Identify appropriate covariates for patient stratification, and 3. Discover drugs targeting these markers in different population.
Investigator's Name: Liewei Wang
Proposed Analysis: Mayo Clinic team Profs. Trushina and Wang are collaborating with Prof.Rima Kaddurah-Daouk and the Alzheimer’s Disease Metabolomics Consortium on this project aiming to identify potentially targetable pathways related to mitochondria metabolism and homeostasis in Alzheimer's disease. Specific aims include: 1. Identify appropriate transcriptomic, proteomic, metabolomic markers associated with bioenergetic deficiency/mitochondria dysfunction 2. Identify appropriate covariates for patient stratification, and 3. Discover drugs targeting these markers in different population.