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Principal Investigator  
Principal Investigator's Name: Dennis van der Meer
Institution: Maastricht University
Department: School of Mental Health and Neuroscience
Country:
Proposed Analysis: 1. Vertex-wise and voxelwise mediation analyses, using T1 MRI data, to identify which brain regions mediate the effects of AD genetic risk variants on AD diagnosis. 2. Replicating loci identified through conditional false discovery rate analysis, conditioning AD GWAS summary statistics on brain morphology GWAS statistics 3. Multimodal hazard scoring, using imaging and genetics data to predict the age of onset of AD.
Additional Investigators  
Investigator's Name: Esmee Breddels
Proposed Analysis: Investigating how structural neuroimaging measures mediate the effects of Alzheimer´s disease risk genes on diagnosis