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Active Investigations

There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.

Principal Investigator  
Principal Investigator's Name: Thomas Tropea
Institution: University of Pennsylvania
Department: Neurology
Country:
Proposed Analysis: I am working with Dr Les Shaw to measure phospho-tau181 in plasma samples from AD/MCI/NC cases. We have proposed a pilot study to measure p-tau181 on the Quanterix SiMoA platform as a validation of a ptau measurements we have already conducted in the UPenn ADRC cohort. We will first evaluate the performance of a plasma p-tau cut point derived from an AD pathology confirmed cohort at UPenn, in clinically-diagnosed AD (50), MCI/PET+(35), MCI/PET-(35), Normal/PET+(35), and Normal/PET-(35) cases. We will subsequently evaluate the performance of the cut point as a predictor for longitudinal cognitive and functional decline among these groups.
Additional Investigators