There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Lin Li |
| Institution: | Qingdao Municipal Hospital |
| Department: | Neurology department |
| Country: | |
| Proposed Analysis: | Roles of gene-environment interaction in development of Alzheimer's disease: implications in prediction, prevention, and pathogenesis.To explore whether and how modifiable environmental factors can interact with genetic factors to modulate cognitive functions, amyloid pathologies, and AD risk.The "environmental (E) elements" are defined as factors such as lifestyle, dietary, comorbidity, drugs, education, and any other modifiable factors reported associated with dementia or cognitive decline. Samples will be categorized into APOE 4 (+) and APOE 4 (-) group and the baseline between-group difference will be compared by Pearson chi-squared test or independent-samples t-test. First, we will compare the E elements between those progressors (defined as individuals diagnosed as AD during the follow-up) and those stable subjects, and tested whether the difference varied with APOE 4 status. Second, the interaction effects of E × Apoe4 will be analyzed: Cross-sectionally, hierarchical regression analyses will be conducted to examine the interaction effects. The overall significance of the interaction term will be assessed by the F-ratio statistics comparing the full model and a nested model that did not include the interaction term. The simple slope analyses will be performed to interpret the interaction effects. Longitudinal analyses will be performed via the linear mixed-effects (LME) regression. The overall significance of the three-way interaction term will be assessed by the likelihood ratio test comparing the full model and a nested model that did not include the three-way interaction term. Statistical comparison of model coefficients to determine the direction of group differences will be performed using the Wald test via the "aod" package.Next, causal mediation analyses will be conducted to examine whether amyloid pathology could modulate the relationship between E and cognition using 10,000 bootstrapped iterations. In addition to amyloid pathology, we will examine whether brain reserve or cerebral glucose metabolism can act as a mediator in modulating the relationship of E with cognitive functions. Finally, the associations between APOE 4 and incident probable AD stratified by E element will be studied by calculating cumulative incidence using the Kaplan-Meier method. |
| Additional Investigators |
