There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Stefan Frenzel |
| Institution: | University Medicine Greifswald |
| Department: | Department of Psychiatry and Psychotherapy |
| Country: | |
| Proposed Analysis: | Imaging data of ADNI will be used to define signatures of AD pathology. Based on these signatures we will derive continous scores of subclinical AD in independent population-based data. This approach has alredy been sucessfully applied in the past using T1-weighted images from the ADNI-1 screening sample [1,2]. We aim to extend these analysis by defining signatures of AD atrophy from 3T instead of 1,5T T1 scans and integrating other modalities (e.g. FLAIR images). [1] Frenzel S, Wittfeld K, Habes M, Klinger-König J, Bülow R, Völzke H, u. a. A Biomarker for Alzheimer’s Disease Based on Patterns of Regional Brain Atrophy. Front Psychiatry. 2020;10. [2] Schwahn C, Frenzel S, Holtfreter B, Van der Auwera S, Pink C, Bülow R, u. a. Effect of periodontal treatment on preclinical Alzheimer’s disease—Results of a trial emulation approach. Alzheimer’s & Dementia. 2022;18(1). |
| Additional Investigators |
