There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Lukas Heumos |
| Institution: | Helmholtz Munich |
| Department: | Institute of Computational Biology |
| Country: | |
| Proposed Analysis: | Our current main focus is/was single-cell analysis of various omics flavors and developing corresponding analysis methods. Inspired by the increasing availability of EHR data we've developed ehrapy (https://github.com/theislab/ehrapy/), a framework for the exploratory analysis of EHR data. Similar to our extremely popular Scanpy framework for single-cell data it includes generalized steps for the preprocessing and embedding of EHR data. To proof that our novel approaches lead to high quality analysis I need access to high quality EHR datasets such as the ADNI dataset. The goal is on a high level: 1. To preprocess (quality control, normalization, feature selection, [...] the ADNI EHR data 2. Embed it into a space with UMAP 3. Cluster with Leiden & annotate clusters based on EHR features and disease stages 4. Determine state transitions with fate mapping 5. Validate everything with statistics |
| Additional Investigators | |
| Investigator's Name: | Philipp Ehmele |
| Proposed Analysis: | As the actual physician he will contribute with medical expertise to the analysis outlined by Lukas Heumos. |
