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Principal Investigator  
Principal Investigator's Name: Da Li
Institution: University of Calgary
Department: Mathematics and Statistics Department
Country:
Proposed Analysis: This research work is to conduct machine learning techniques to determine the stage of AD. Moreover, the long-term goal of this work is to construct a workflow through machine learning and GWAS technology to analyze the effects of human genes on brain MRI and AD stage. To achieve this goal, we carry out the following studies: - Design a new neural net model based on U-Net and traditional convolution neural network to achieve a better performance of AD detection. - Include a priori information such as imaging and AD stage to increase the machine learning model performance, e.g., accuracy and training speed. - Extract brain MRI imaging-derived phenotypes (IDPs) with a data-driven strategy by using machine learning technique. Then, the extracted IDPs will be accessed with the GWAS technique.
Additional Investigators