There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Seyed Hani Hojjati |
| Institution: | Weill Cornell Medicine |
| Department: | Radiology |
| Country: | |
| Proposed Analysis: | The aggregation of neurofibrillary tau tangles is one of the well-documented pathologies for Alzheimer’s disease (AD). The low-level tangle deposition is in part an aging phenomenon and there are strong reports about the effect of b-amyloidosis as a trigger to neurofibrillary tangle progression especially out of the medial temporal lobe region. This study aim is to show the negative association as a distinctive association between abnormal levels of tau accumulation and aging. Opposed the positive association between tau accumulations and age, the negative association is a unique relationship that rarely reported by previous studies. We used 394 healthy control (HC) and 52 mild cognitive impairments (MCI) Amyloid and tau positron emission tomography (PET) images from five separate research cohorts at Columbia University Irving Medical Center and Weill Cornell Medicine. To replicate the results, we need Alzheimer's Disease Neuroimaging Initiative (ADNI) data with different PET tracers. |
| Additional Investigators |
