There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Zhen Liu |
| Institution: | Peking University |
| Department: | National Institute on Drug Dependence |
| Country: | |
| Proposed Analysis: | GWAS and meta-analysis studies have verified that the PICALM rs541458 polymorphism is a susceptible site for late-onset AD in Caucasians. Age is also a critical risk factor for AD. We hypothesized that age might modulate the effects of PICALM rs541458 polymorphism on brain structure and function in the cognitively normal, MCI and AD cohort. Thus, we first intended to examine whether the effects of rs541458 on cognitive functions were modulated by age. Second, we intended to investigate this modulated effect of age on resting-state functional connectivity, gray matter volume and white matter structure. |
| Additional Investigators |
