There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Erin Sundermann |
| Institution: | Albert Einstein College of Medicine |
| Department: | Psychiatry |
| Country: | |
| Proposed Analysis: | We propose to examine the impact of sex on the correlation between Alzheimer's disease neuropathology on PET (PIB burden) and clinical manifestation of the disease and whether cognitive reserve moderates this effect. We plan to use ADNI diagnostic summary data as our measure of clinical manifestation and ANART scores and years of education as a measure of cognitive reserve. Through this project, we hope to help identify male/female differences in the pathogenesis and presentation of Alzheimer’s disease (AD) in the early and late stages of the disease. Our impetus behind this specific investigation is a previous finding from the Einstein Aging Study that individuals with higher education begin to experience acceleration in cognitive decline closer to the time of AD diagnosis than individuals with lower education, but that their rate of decline is more rapid after the time of acceleration due to increased disease burden. Secondly, the association between AD pathology and clinical AD is significantly stronger in women than men so that women are at a higher risk of clinical AD than men with the same degree of neuropathology. |
| Additional Investigators | |
| Investigator's Name: | Tasnuva Chowdhury |
| Proposed Analysis: | Ms. Chowdhury will assist in a project examining sex differences in the clinical trajectory of Alzheimer's disease and in the relationship between AD biomarkers and clinical symptoms. |
