ADNI | Active Investigations

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Active Investigations

There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.

Principal Investigator
Principal Investigator's Name:	Elizabeth Menten
Institution:	NYU Grossman School of Medicine
Department:	School of Medicine
Country:
Proposed Analysis:	We aim to validate the previously described non-monotonic relationship between increasing cerebral amyloid deposition and changes in white and grey matter microstructure in preclinical Alzheimer’s disease (AD). Additionally, we aim to analyze this relationship in the context of the biphasic model of structural brain changes in preclinical AD proposed by recent research. We will conduct a retrospective study of clinical MRI data to investigate this question. Specifically, we will investigate the diffusion kurtosis properties of subjects in Stage 1 of Alzheimer’s disease, stratified into three subject groups by their Aβ burden -- Aβ+, Aβ-, and Aβ “intermediate” (Aβi). We hypothesize that subjects in the Aβi group will show more restricted diffusion as compared to both the Aβ- and Aβ+ groups.
Additional Investigators
Investigator's Name:	Ricardo Osorio
Proposed Analysis:	We aim to validate the previously described non-monotonic relationship between increasing cerebral amyloid deposition and changes in white and grey matter microstructure in preclinical Alzheimer’s disease (AD). Additionally, we aim to analyze this relationship in the context of the biphasic model of structural brain changes in preclinical AD proposed by recent research. We will conduct a retrospective study of clinical MRI data to investigate this question. Specifically, we will investigate the diffusion kurtosis properties of subjects in Stage 1 of Alzheimer’s disease, stratified into three subject groups by their Aβ burden -- Aβ+, Aβ-, and Aβ “intermediate” (Aβi). We hypothesize that subjects in the Aβi group will show more restricted diffusion as compared to both the Aβ- and Aβ+ groups.