There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Dorie-Mae Nicolas |
| Institution: | Hoag |
| Department: | Neuroscience |
| Country: | |
| Proposed Analysis: | Smoking and Socioeconomic Status: Do a combination of both factors worsen cognitive performance? In 2020, approximately 30.8 million adults in the United States were current cigarette smokers, while 16 million Americans lived with a smoking-related disease (Cornelius et al., 2022). Current cigarette smoking prevalence was higher among individuals residing in rural areas with lower educational attainment and an annual household income of less than $35 000 (Cornelius et al., 2022). Research has shown a relationship between cigarette smoking and an increased risk of cognitive decline and dementia in older adults (Anstey et al., 2007; Debette et al., 2011; Weuve et al., 2012) which seems to arise from cardiovascular processes in the brain as observed in brain imaging (Anstey et al., 2007; Friedman et al., 2014). Notably, recent studies revealed that current smoking is linked to smaller total and regional gray matter volumes (Elbejjani et al., 2019), poorer performance on measures of verbal memory, lower hippocampal volumes (Wu et al., 2020), and poorer performance on selective attention, working memory, short-term memory, long-term memory, and executive function (Lewis, 2021; Nadar et al., 2021) to name a few. Similarly, numerous population-based studies have revealed a relationship between sociodemographic factors of lower education and income with lower scores on cognitive testing (Migeot et al., 2022; Muhammad et al., 2022; Yang et al., 2016). Given that tobacco smoking and sociodemographic are strongly associated with cognitive functioning, the current study seeks to examine the relationships among smoking, SES factors, and cognition. |
| Additional Investigators |
