There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Manuel Pfeuffer |
| Institution: | Humboldt University of Berlin |
| Department: | Chair of Statistics |
| Country: | |
| Proposed Analysis: | In this project, we will develop and benchmark methods for shapes of brain structures obtained from structural magnetic resonance imaging (MRI) as either inputs or outputs that respect their geometry. We combine the strengths of flexible model-based statistical learning approaches – interpretability, adjustment for confounders and temporal dependence structure – with those from deep learning – in particular predictive performance and scalable software solutions. To better understand the relationship of object biomarkers with a number of health-related variables including age and disease status, by building more valid and interpretable models, we will test these methods on shape data obtained from the longitudinal Alzheimer’s Disease Neuroimaging Initiative database. |
| Additional Investigators |
