There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Xiaoxiao Wang |
| Institution: | Peking University Third Hospital |
| Department: | Research Center of Clinical Epidemiology |
| Country: | |
| Proposed Analysis: | Proposed Analysis 1 Objective: To determine whether MRI-based cerebral small vessel disease (CSVD) burden assessment, in addition to clinical and CT data, improved prediction of cognitive impairment among participants with CSVD at baseline. Methods: We analyzed data among participants with CSVD at baseline from the Alzheimer’s Disease Neuroimaging Initiative. Cox proportional hazards models adjusted for potential confounders were used in the time to event analysis with progression to dementia as outcome. Proposed Analysis 2 Objective: To determine the association of blood pressure lowering or types of antihypertensive medications (AHMs) (angiotensin-II receptor blocker, ARB vs angiotensin-converting enzyme inhibitor, ACEI) with progression to dementia or cognitive impairment among participants with cerebral small vessel disease (CSVD) at baseline. Methods: We analyzed data among participants with CSVD at baseline from the Alzheimer’s Disease Neuroimaging Initiative. Cox proportional hazards models adjusted for potential confounders were used in the time to event analysis with progression to dementia as outcome. |
| Additional Investigators | |
| Investigator's Name: | Youyou Ying |
| Proposed Analysis: | To investigate associations between statin use and cognitive change, as well as diagnostic conversion, in individuals with cognitively normal (CN) status, mild cognitive impairment (MCI), and dementia due to Alzheimer disease (AD-dementia). |
