There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Yi Si |
| Institution: | Nanjing University |
| Department: | College of Electronic Information Science Engineer |
| Country: | |
| Proposed Analysis: | A literature search on PubMed was conducted using permutations of six terms relating to FDG-PET, AD, and MCI in order to identify studies that carried out direct whole-brain contrasts of FDG data and reported Z-scores or T-values corresponding to MNI or Talairach coordinates that represented regions in which FDG uptake differed significantly between patients (AD or MCI) and controls. This resulted in a total of 15 studies involving a cross-sectional comparison of AD, MCI, and/or Normal groups and 178 MNI and Talairach coordinates. A spreadsheet of these coordinates, associated t-values or z-scores was created. Talairach coordinates were transformed into MNI space, and t-values were converted to z-scores, which were then mapped to the space of the MNI template brain as intensity values. There were 14 overlapping coordinates, and their z-scores were added. Resulting images were smoothed with a standard 14 mm FWHM kernel. The values of all voxels in the image were then normalized, resulting in an image with values between 0 and 1. |
| Additional Investigators |
