There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Peter Olejua |
| Institution: | University of South Carolina |
| Department: | Epidemiology and Biostatistics |
| Country: | |
| Proposed Analysis: | Greetings, I hope this message find you well, I am Peter Olejua Ph.D. student in Biostatistics at the University of South Carolina. As part of our course in survival analysis and aiming at a future dissertation. I would like to request access to the ADNI-1 and ADNI-2 data sets. The project compares supervised and unsupervised Functional Principal Components Analysis to analyze time-to-event outcomes when we have functional outcomes. Thre main papers already use this data set: 1- Shi H, Jiang S, Cao J. Dynamic prediction with time-dependent marker in survival analysis using supervised functional principal component analysis. Statistics in Medicine. 2022;41(18):3547-3560. doi: 10.1002/sim.9433 2- Yang H, Zhu H, Ahn M, Ibrahim JG. Weighted functional linear Cox regression model. Statistical Methods in Medical Research. 2021;30(8):1917-1931. doi:10.1177/09622802211012015 3- Kong D, Ibrahim JG, Lee E, Zhu H. FLCRM: Functional linear cox regression model. Biometrics. 2018 Mar;74(1):109-117. doi: 10.1111/biom.12748. Epub 2017 Sep 1. PMID: 28863246; PMCID: PMC5832538. ------------------------------------ Data requested: Subset of patients who have been diagnosed with mild cognitive impairment (MCI) Variables requested: time-to-event outcome: - Onset of dementia (AD) since MCI Functional predictors: - Alzheimer’s Disease Assessment Scale-Cognitive 13 items (ADAS-13) as the time-varying neurocognitive marker for each visit (ADNI 1 every 6 months, ADNI-2 annual). - Hippocampal surface morphology at baseline: Hippocampal radial distances of 30,000 surface points on the left and right hippocampus surfaces. The radial distance is defined as the distance between the medial core of the hippocampus and the corresponding vertex. Other covariates: -Gender -Handedness -Marital Status -Education length -Retirement -Age -APOE genetype |
| Additional Investigators | |
| Investigator's Name: | Nasim Nishat |
| Proposed Analysis: | Co-investigator in Comparison of FPCA methods for survival analysis with Functional biomarkers. |
