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Principal Investigator  
Principal Investigator's Name: Manikandan Narayanan
Institution: IIT Madras
Department: Computer Science and Engineering
Country:
Proposed Analysis: We would like to use the ADNI data for causal discovery applications using methods based on MR (Mendelian Randomization), Fast Causal Inference, etc. to arrive at causal gene-gene/gene-SNP network models for AD. Furthermore, we would like to use the GWAS and genotype data from ADNI to compute ethnicity and pathway specific genetic risk scores.
Additional Investigators  
Investigator's Name: Ritwiz Kamal
Proposed Analysis: We would like to use the ADNI data for causal discovery applications using methods based on MR (Mendelian Randomization), Fast Causal Inference, etc. to arrive at causal gene-gene/gene-SNP network models for AD. Furthermore, we would like to use the GWAS and genotype data from ADNI to compute ethnicity and pathway specific polygenic risk scores (PRS). I will also explore extensions of the causal discovery or PRS methods.
Investigator's Name: Sanga Mitra
Proposed Analysis: We would like to use the ADNI data for causal discovery applications using methods based on MR (Mendelian Randomization), Fast Causal Inference, etc. to arrive at causal gene-gene/gene-SNP network models for AD. Furthermore, we would like to use the GWAS and genotype data from ADNI to compute ethnicity and pathway specific polygenic risk scores (PRS). I will also explore biological interpretations of the aforementioned analyses involving pathways and causal gene networks.